Endocrine Abstracts

Introduction: Primary hyperparathyroidism (PHPT) is commonly the most early manifestation of multiple endocrine neoplasia syndrome type 1 (MEN1), but it can also occur in young patients without any inherited disorders. The aim of our study was to compare the clinical characteristics of PHPT in young patients with MEN1 syndrome and with sporadic disease.Patients and Methods: The study included 72 patients with MEN-1 associated PHPT and 168 patients with s...

Introduction: Today simultaneous pancreas-kidney transplantation (SPKT) is an effective method of treatment for patients with type 1 diabetes mellitus (T1D) and terminal stage of diabetic nephropathy (DN) on renal replacement therapy by hemodialysis. It solves several problems: reduces the severity of intoxication syndrome, contributes to the achievement of euglycemia in most cases, that allows to delay progression of micro- and macrovascular diabetic complications. Case Descr...

Introduction: Pseudohypoparathyroidism (PHP) is an orphan disease caused by a mutation in the GNAS gene encoding the α-subunit of G-protein. PHP is characterized by multihormonal resistance. A correlation between the genotype and phenotype of patients with GNAS mutations hasn’t yet been described.Clinical Case: Patient T., 19 years old male, admitted to our Centre with general weakness and overweight. Hypocalcemia, hyperphosph...